Tissue Plasminogen Activator FDA Link

A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.

Also Known As:

Alteplase; Activase; T-Plasminogen Activator; Actilyse; Lysatec rt-PA; TTPA; Tisokinase; Tissue Activator D-44; Lysatec rt PA; Lysatec rtPA; Plasminogen Activator, Tissue; Plasminogen Activator, Tissue Type; T Plasminogen Activator; Tissue Activator D 44; Tissue Type Plasminogen Activator; Plasminogen Activator, Tissue-Type; Tissue-Type Plasminogen Activator

Pharmalogical Action Categories:

Fibrinolytic Agents

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Hydrolases: 2206
    - Peptide Hydrolases: 24289
      - Serine Proteases: 3808
        Serine Endopeptidases: 11
        Tissue Plasminogen Activator: 10761
      - Endopeptidases: 643
        Serine Endopeptidases: 11
        Tissue Plasminogen Activator: 10761
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Blood Proteins: 12679
    - Blood Coagulation Factors: 5500
      - Plasminogen Activators: 5226
        Tissue Plasminogen Activator: 10761
Biological Factors: 2560
- Blood Coagulation Factors: 5500
  - Tissue Plasminogen Activator: 10761

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Disease

Drug/Important Bio-Agent (IBA)